Tetrahedron

Hydro-de-halogenation and consecutive deprotection of chlorinated N-amido-pyrrolidin-2-ones with Raney-Ni: an effective approach to gabapentin

…, F Ghelfi, UM Pagnoni, AF Parsons, L Schenetti

Index: Cagnoli, Rita; Ghelfi, Franco; Pagnoni, Ugo M.; Parsons, Andrew F.; Schenetti, Luisa Tetrahedron, 2003 , vol. 59, # 50 p. 9951 - 9960

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Citation Number: 28

Abstract

The benzoylamino group was identified as a useful radical cyclization auxiliary that can be smoothly removed on hydro-de-halogenation of chlorinated N-substituted-pyrrolidin-2-ones with Raney-Ni. This methodology was successfully implemented in a new and appealing route to the anti-epileptic drug gabapentin.