A modified procedure for the preparation of 2, 5-dihydropyrrole (3-pyrroline)

JS Warmus, GJ Dilley, AI Meyers

Index: Warmus, Joseph S.; Dilley, Garrett J.; Meyers, A. I. Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 270 - 271

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Citation Number: 19

Abstract

During our studies of elaborating chiral 3-pyrrolines containing the formamidine moietys into various 2-substituted pyrrolidines,'we required considerable quantities of 2, 6-dihydropyrrole 1 (Scheme I). We had previously utilized commercially available 3-pyrroline which contained 15% pyrrolidine? and this required chromatographic separation at the formamidine stage to reach pure 2. More recently, however, 1 is available in only 65% purity? and it is possible ...