Evaluation and synthesis of amino-hydroxy isoxazoles and pyrazoles as potential glycine agonists

J Drummond, G Johnson, DG Nickell…

Index: Drummond, J.; Johnson, G.; Nickell, D. G.; Ortwine, D. F.; Bruns, R. F.; Welbaum, B. Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2116 - 2128

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Citation Number: 32

Abstract

Except for structurally similar small amino acids, such as alanine, p-alanine, and serine, compounds acting as glycine-receptor agonists are an unknown class of pharmacological agents. To investigate the potential of small, substituted heterocycles to act as glycine agonists, we have evaluated the similarities between glycine and a series of hydroxy-and amino-substituted pyrazoles and isoxazoles through complementary molecular modeling ...