The benzoylation of uracil and thymine

KA Cruickshank, J Jiricny, CB Reese

Index: Cruickshank, Kenneth A.; Jiricny, Josef; Reese, Colin B. Tetrahedron Letters, 1984 , vol. 25, # 6 p. 681 - 684

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Citation Number: 155

Abstract

Abstract Uracil and thymine react with benzoyl chloride in acetonitrile-pyridine solution at room temperature to give first their 1-N-benzoyl (2b and 3b) and then their 1-N, 3-N- dibenzoyl derivatives (4a and 4b, respectively); the latter compounds are converted into the corresponding 3-N-benzoyl derivatives (5a and 6a) under mild conditions of basic hydrolysis.