(2 S, 3 S)-3-Amino-4-(3, 3-difluoropyrrolidin-1-yl)-N, N-dimethyl-4-oxo-2-(4-[1, 2, 4] triazolo [1, 5-a]-pyridin-6-ylphenyl) butanamide: A Selective α-Amino Amide …

SD Edmondson, A Mastracchio…

Index: Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3614 - 3627

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Citation Number: 90

Abstract

... Journal of Medicinal Chemistry. ... Cyanopyrrolidines such as 1 and 2 are representative of this potent class of DPP-4 inhibitors, and each of these compounds has been optimized with respect to chemical stability and potency. ...