Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines

…, M Mikyna, M Reichert, M Leippe, R Brun…

Index: Bringmann, Gerhard; Gampe, Christian M.; Reichert, Yanina; Bruhn, Torsten; Faber, Johan H.; Mikyna, Martin; Reichert, Matthias; Leippe, Matthias; Brun, Reto; Gelhaus, Christoph Journal of Medicinal Chemistry, 2007 , vol. 50, # 24 p. 6104 - 6115

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Citation Number: 12

Abstract

The naphthylisoquinoline (NIQ) alkaloids from tropical Ancistrocladaceae and Dioncophyllaceae plants show high antiplasmodial activities in vitro and in vivo, even against chloroquine-resistant strains of the malaria pathogen. For the directed optimization of these activities, an investigation of the mode of action seems most rewarding. We have therefore embarked on the identification of the respective target protein in Plasmodium ...