Pteridine–sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity

…, CT Supuran, NI Krupenko, SA Krupenko…

Index: Marques, Sergio M.; Enyedy, Eva A.; Supuran, Claudiu T.; Krupenko, Natalia I.; Krupenko, Sergey A.; Amelia Santos Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 5081 - 5089

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Citation Number: 30

Abstract

Recent evidences suggest that cancer treatment based on combination of cytostatic and conventional chemostatic therapeutics, which are usually cytotoxic, can provide an improved curative option. On the sequence of our previous work on methotrexate (MTX) derivatives, we have developed and evaluated novel MTX analogues, containing a pteridine moiety conjugated with benzenesulfonamide derivatives, thus endowed with the potential ...