Tetrahedron

Solid phase synthesis of benzothiazole and thiophene derivatives based on resin-bound cyclic malonic acid ester

X Huang, J Tang

Index: Huang, Xian; Tang, Jing Tetrahedron, 2003 , vol. 59, # 26 p. 4851 - 4856

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Citation Number: 23

Abstract

A new method for the solid phase synthesis of benzothiazoles and 2-arylamino-3-carboxyl-4- hydroxy-5-arylthiophenes is described. Resin bound cyclic malonic acid ester was reacted with aryl isothiocyanates and then with bromine or α-bromoketones, followed by treatment with perchloric acid or sodium methoxide to afford substituted 2-methylbenzothiazoles or 2- arylamino-3-carboxyl-4-hydroxy-5-arylthiophenes, respectively, in high yields and purities.

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