Synthesis of peptides by the solid-phase method. 7. Substance P and analogs

…, D Regoli, M Gendreau, S St-Pierre

Index: Fournier; Couture; Regoli; Gendreau; St-Pierre Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 64 - 68

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Citation Number: 32

Abstract

Substance P and 21 related peptides containing isosteric or isofunctional groups were prepared by the solid-phase method. After purification by gel filtration and ion-exchange chromatography, the compounds were characterized by thin-layer chromatography, paper electrophoresis, and amino acid and elemental analysis. The biological activities of the peptides were evaluated in vitro on the guinea pig ileum, the rabbit mesenteric vein, and ...