Syntheses of 2-(bromodifluoromethyl) benzoxazole and 5-(bromodifluoromethyl)-1, 2, 4-oxadiazoles

WR Dolbier, CR Burkholder, M Médebielle

Index: Dolbier Jr., William R.; Burkholder, Conrad R.; Medebielle, Maurice Journal of Fluorine Chemistry, 1999 , vol. 95, # 1-2 p. 127 - 130

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Citation Number: 27

Abstract

Facile syntheses of CF2Br-substituted heterocycles are reported. Preparation of 2- (bromodifluoromethyl) benzoxazole (2) was achieved in two steps by reaction of 2- aminophenol (3) with CF2BrCO2Et to give amide (4), followed by cyclization of 4 with PPA to give 2. The 5-(bromodifluoromethyl)-1, 2, 4-oxadiazoles (6a–c) were prepared by one step reaction of amidoximes (5a–c) with CF2BrCO2Et. These CF2Br-substituted heterocycles ...