Mild Electrophilic Trifluoromethylation of Carbon??and Sulfur??Centered Nucleophiles by a Hypervalent Iodine (III)–CF3 Reagent

I Kieltsch, P Eisenberger, A Togni

Index: Kieltsch, Iris; Eisenberger, Patrick; Togni, Antonio Angewandte Chemie - International Edition, 2007 , vol. 46, # 5 p. 754 - 757

Full Text: HTML

Citation Number: 350

Abstract

Fluorinated and perfluoroalkylated organic compounds constitute important targets in many research fields both in academia and in industry.[1] One of the most challenging synthetic problems is the introduction of a trifluoromethyl group in a mild and selective manner. Thus, trifluoromethylation reactions that could be implemented at a late stage of a multistep synthetic sequence are still highly sought after. These reactions should also be ...