Tetrahedron letters

Synthesis of 1, 3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence

JM Salovich, CW Lindsley, CR Hopkins

Index: Salovich, James M.; Lindsley, Craig W.; Hopkins, Corey R. Tetrahedron Letters, 2010 , vol. 51, # 29 p. 3796 - 3799

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Citation Number: 16

Abstract

Herein we report a general synthesis of 1, 3-diarylsubstituted indazoles utilizing a two-step Suzuki cross-coupling/deprotection/N-arylation sequence. This procedure proceeds in excellent overall yield starting from the 3-iodo-N-Boc indazole derivative allowing for rapid access to these compounds.