Spirocycle assembly through selective tandem ring closing metathesis reactions

MJ Bassindale, P Hamley, A Leitner, JPA Harrity

Index: Bassindale, Martin J.; Hamley, Peter; Leitner, Andreas; Harrity, Joseph P. A. Tetrahedron Letters, 1999 , vol. 40, # 16 p. 3247 - 3250

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Citation Number: 100

Abstract

A range of functionalised spirocyclic systems have been prepared under mild and neutral conditions by tandem selective ring closing olefin metathesis reactions. Additionally, a marked preference for 5-membered ring closure over 7-membered ring closure was observed which appears to be a result of a kinetically favoured cyclisation process.