Natural α-amino acids applied in the synthesis of imidazo [1, 5-a] N-heterocycles under mild conditions

Q Wang, S Zhang, F Guo, B Zhang, P Hu…

Index: Wang, Qiang; Zhang, Shuai; Guo, Fengfeng; Zhang, Baiqun; Hu, Ping; Wang, Zhiyong Journal of Organic Chemistry, 2012 , vol. 77, # 24 p. 11161 - 11166

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Citation Number: 32

Abstract

A facile iodine-mediated decarboxylative cyclization from α-amino acids and N-heterocyclic carbaldehydes was developed. By virtue of this method, a series of imidazo [1, 5-a] N- heterocycles can be synthesized efficiently under mild conditions. A tentative reaction mechanism was proposed based on the experimental results and previous reports.

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