Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases

…, F Buffoni, G Ignesti, N Picci, S Trombino…

Index: Bertini, Vincenzo; Buffoni, Franca; Ignesti, Giovanni; Picci, Nevio; Trombino, Sonia; Iemma, Francesca; Alfei, Silvana; Pocci, Marco; Lucchesini, Francesco; De Munno, Angela Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 664 - 670

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Citation Number: 15

Abstract

The first substratelike, reversible inhibitors of different copper amine oxidases (CAOs) with IC50 (M) as low as 2.0× 10-8 corresponding to derivatives of 4-aminomethylpyridine with alkoxy (1a-d), alkylthio (2a, b), and alkylamino (3a-e, 4a-j) groups in the positions 3 and 5 have been prepared and studied. The inhibitors 1a-d are active on benzylamine oxidase and semicarbazide-sensitive amine oxidase and are very selective with respect to ...