Green Chemistry

Synthesis of 2-aminobenzothiazole via FeCl3-catalyzed tandem reaction of 2-iodoaniline with isothiocyanate in water

Q Ding, B Cao, X Liu, Z Zong, YY Peng

Index: Ding, Qiuping; Cao, Banpeng; Liu, Xianjin; Zong, Zhenzhen; Peng, Yi-Yuan Green Chemistry, 2010 , vol. 12, # 9 p. 1607 - 1610

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Citation Number: 45

Abstract

An FeCl3-catalyzed tandem reaction of 2-iodoaniline with isothiocyanate in water is described, which provides an environmentally benign, efficient, and practical route for the generation of 2-aminobenzothiazole. This present tandem process shows broad substrate scope in the presence of octadecyltrimethylammonium chloride as a phase-transfer catalyst. In addition, the reaction media can be recovered and recycled without loss of efficiency.

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