A Substrate??Driven Approach to Determine Reactivities of α, β??Unsaturated Carboxylic Esters Towards Asymmetric Bioreduction

…, WMF Fabian, M Hall, K Ditrich, K Faber

Index: Tasnadi, Gabor; Winkler, Christoph K.; Clay, Dorina; Sultana, Nargis; Fabian, Walter M. F.; Hall, Melanie; Ditrich, Klaus; Faber, Kurt Chemistry - A European Journal, 2012 , vol. 18, # 33 p. 10362 - 10367

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Citation Number: 23

Abstract

Abstract The degree of C [DOUBLE BOND] C bond activation in the asymmetric bioreduction of α, β-unsaturated carboxylic esters by ene-reductases was studied, and general recommendations to render these “borderline-substrates” more reactive towards enzymatic reduction are proposed. The concept of “supported substrate activation” was developed. In general, an additional α-halogenated substituent proved to be beneficial for enzymatic ...