Synthetic communications

Synthesis of Fused [5, 5]??1, 2, 4??Triazoles via Tandem Thioimidate Cyclopropane Rearrangement–Cyclization

C Ng Di Marco, SD Kuduk

Index: Di Marco, Christina Ng; Kuduk, Scott D. Synthetic Communications, 2006 , vol. 36, # 22 p. 3377 - 3386

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Citation Number: 3

Abstract

Abstract The synthesis of fused [5, 5]??1, 2, 4??triazoles via a tandem cyclopropane rearrangement–cyclization sequence is described. Optimization of the cyclization reaction was achieved thermally using i PrOH as the solvent in the presence of TEA. This method was applied to the preparation of 3??substituted??7??aryl??pyrrolo??1, 2, 4??triazoles in good to excellent yields.