Journal of the American Chemical Society

Antispasmodics. III. Basic Alkyl Ester Acid Addition and Quaternary Ammonium Salts of α-(2-Cycloalken-1-yl)-2-thienylacetic Acids

F Leonard, L Simet

Index: Leonard; Simet Journal of the American Chemical Society, 1955 , vol. 77, p. 2855,2857

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Citation Number: 8

Abstract

The synthesis, antispasmodic activity and toxicity of a number of 2-diethylaminoethyl ester hydrochlorides of a-substituted 2-thienylacetic acids were reported in the first paper2 of this series. Two of the compounds described therein, namely, 2-diethylaminoethyl a-(Z- cyclopenten-l-yI)-Z-thi-enylacetate hydrochloride [I, R= 1-(2-C5H7) l3 and its 2-cyclohexen-1- yl homolog [I, R= 1-(2-CoHg)] were found to possess in vitro and in vivo antispasmodic ...