Hypolipidemic activity of 4??substituted 1, 2??diacyl??1, 2, 4??triazolidine??3, 5??diones in rodents

R Simlot, RA Izydore, OT Wong…

Index: Simlot; Izydore; Wong; Hall Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 3 p. 367 - 371

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Citation Number: 23

Abstract

Abstract A series of 4-substituted 1, 2-diacyl-1, 2, 4-triazolidine-3, 5–diones were synthesized and shown to be hypolipidemic in rodents; serum cholesterol and triglyceride levels were significantly reduced following intraperitoneal and oral dosing at 20 mg/kg/day. The hypolipidemic activity of the triazolidine-3, 5-diones was improved when R 1 was either a phenyl or a butyl group. Tissue lipid levels were reduced in the liver, aorta, and small ...