Bioorganic & medicinal chemistry letters

Discovery of a potent, non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase

SW Lin, YL Lin, TC Lin, DY Yang

Index: Lin, Shean-Woei; Lin, Yun-Loung; Lin, Tzu-Ching; Yang, Ding-Yah Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1297 - 1298

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Citation Number: 17

Abstract

3-Cyclopropanecarbonyloxy-2-cyclohexen-1-one has been found to be a new, potent, low molecular weight non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase with IC50 value of 30 nM. Preliminary studies suggest that the two carbonyl groups present in the compound are crucial for the inhibition activity.