Co-operative effects of functional groups in peptides. I. Aspartyl-serine derivatives

SA Bernhard, A Berger, JH Carter…

Index: Bernhard,S.A. et al. Journal of the American Chemical Society, 1962 , vol. 84, p. 2421 - 2434

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Citation Number: 90

Abstract

The@-benzyl esters of N-carbobenzyloxyaspartyl amides and peptides were found to undergo rapid saponification in dioxane-water mixtures. A study of the saponification rates of a number of these derivatives revealed a strong rate dependence on the nature of the particular amide or peptide. A general mechanism for these saponifications involving the formation of an imide intermediate is proposed. The intermediate has been detected both ...