Tetrahedron Letters

An improved amide coupling procedure for the synthesis of N-(pyridin-2-yl) amides

AT Londregan, G Storer, C Wooten, X Yang…

Index: Londregan, Allyn T.; Storer, Gregory; Wooten, Ceshea; Yang, Xiaojing; Warmus, Joseph Tetrahedron Letters, 2009 , vol. 50, # 17 p. 1986 - 1988

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Citation Number: 12

Abstract

The amide bond is an ubiquitous connection in proteins and peptides and is found in a large number of small-molecule chemotherapeutics. 1 Unsurprisingly, the preparation of amide bonds is among the most common synthetic transformations in organic chemistry. Most methods employ the dehydrative coupling of carboxylic acids with amines. The literature is replete with coupling reagents and additives 2 which facilitate this transformation. When the acylations are ...

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