Base??Mediated Tandem Reaction Consisting of an Acyl Shift Strategy Leading to 4, 5??Disubstiuted Furan??2 (5H)??ones

…, ZQ Wang, YX Xie, SC Yu, BX Tang…

Index: Lei, Yong; Wang, Zhi-Qiang; Xie, Ye-Xiang; Yu, Shang-Ci; Tang, Bo-Xiao; Li, Jin-Heng Advanced Synthesis and Catalysis, 2011 , vol. 353, # 1 p. 31 - 35

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Citation Number: 5

Abstract

Abstract The first example of the synthesis of 4, 5-disubstiuted furan-2 (5H)-ones by base- mediated tandem acyl shift/cyclization/decarbonylation reactions of aroylmethyl 2- alkynoates has been developed. This new and inexpensive tandem route allows both a C [BOND] O bond and a Csp 3 [BOND] Csp 2 bond forming in one step involving an unprecedented acyl rearrangement process.

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