Direct, rapid and convenient synthesis of esters and thioesters using PPh3/N-chlorobenzotriazole system

H Rouhi-Saadabad, B Akhlaghinia

Index: Rouhi-Saadabad, Hamed; Akhlaghinia, Batool Journal of the Brazilian Chemical Society, 2014 , vol. 25, # 2 p. 253 - 263

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Citation Number: 6

Abstract

Esterification is the fundamental and routinely used functional group transformation in organic chemistry 1 and it is extensively employed for the protection and further manipulation of the carboxylic acid functional group as well as the synthesis of natural products. Traditionally, the simple condensation between a carboxylic acid and an alcohol is the most straightforward way to esterification. The difficulty stems primarily from the equilibration of the condensation reaction. The ...

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