A new general reaction for preparing gem dinitro compounds: oxidative nitration

RB Kaplan, H Shechter

Index: Kaplan,R.B.; Shechter,H. Journal of the American Chemical Society, 1961 , vol. 83, p. 3535 - 3536

Full Text: HTML

Citation Number: 83

Abstract

The anomalous results reported recently by Steinmanl6 using the manometric assay for studying the rate of 6-APA hydrolysis by penicillinase can be explained by reaction of some of the carbon dioxide with 6-APA to form &HPA. It seems likely that nearly everyone working with 6-aminopenicillanic acid will, at some time, by chance or by design prepare 8- hydroxypenillic acid.