Synthesis

Synthesis of Aminopyridazines from Azidopyridazines and Tetrazolo [1, 5-b] pyridazines

T Kappe, A Pfaffenschlager, W Stadlbauer

Index: Kappe, Th.; Pfaffenschlager, A.; Stadlbauer, W. Synthesis, 1989 , # 9 p. 666 - 671

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Citation Number: 18

Abstract

However, reaction of the tetrazole 10 with triphenylphosphine in boiling benzene affords in 70% yield the open chain phosphazene 11, which can easily by hydrolyzed to the aminopyr- idazine 12. A problem exists in the isolation of the 3-amino-5-hydroxy~ 6-phenyl-pyridazine (12) when using the standard hy-drolysis method with aqueous hydrochloric acid (procedure D. 1 in the experimental part), as described in the Staudinger method “and used in various ...