Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation.

S Rahman, N Fukamiya, N Ohno, H Tokuda…

Index: Rahman, Shakila; Fukamiya, Narihiko; Ohno, Nobuhiro; Tokuda, Harukuni; Nishino, Hoyoku; Tagahara, Kiyoshi; Lee, Kuo-Hsiung; Okano, Masayoshi Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 4 p. 675 - 677

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Citation Number: 28

Abstract

Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for semisynthetic quassinoids (3-7), which were obtained by esterification of the C-15 OH group of deacetylated isobrucein-B (2). All the ester derivatives showed higher antitumor promoting activity than that of the potent compound 2. A compound containing a fluorinated aliphatic ester showed the highest potency.

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