Synthesis and evaluation of. alpha.-[[(2-haloethyl) amino] methyl]-2-nitro-1H-imidazole-1-ethanols as prodrugs of. alpha.-[(1-aziridinyl) methyl]-2-nitro-1H-imidazole-1- …

…, MA Naylor, P O'Neill, MD Threadgill…

Index: Jenkins, Terence C.; Naylor, Matthew A.; O'Neill, Peter; Threadgill, Michael D.; Cole, Shirley; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2603 - 2610

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Citation Number: 71

Abstract

It is generally known that many solid tumors contain areas of diminished oxygen supply. While the underlying reasons for this hypoxia can vary depending upon the type and environment of the tumor, this phenomenon provides a potential basis for selectivity of cancer chemotherapeutic agents towards tumors. Compounds which are anaerobically reduced to a cytotoxin should be more cytotoxic to hypoxic tumor cells than to oxygenated ...