Tetrahedron Letters

Iron-catalyzed indirect hydration of alkynes in presence of methanesulfonic acid

J Park, J Yeon, PH Lee, K Lee

Index: Park, Jungmin; Yeon, Jihee; Lee, Phil Ho; Lee, Kooyeon Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4414 - 4417

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Citation Number: 30

Abstract

Abstract We have demonstrated that the FeCl 2· 4H 2 O and methanesulfonic acid systems show high reaction efficiency for the indirect hydration of various alkynes in DCE. The reaction proceeds under mild conditions to produce various ketones from alkynes. A mechanistic study of the reaction intermediates showed that the alkyne was readily converted into vinyl sulfonate corresponding to the addition of MsOH to the C–C triple ...

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