Straightforward synthesis of indolizidine alkaloid 167B

S Gracia, R Jerpan, S Pellet-Rostaing, F Popowycz…

Index: Gracia, Stephanie; Jerpan, Rudolf; Pellet-Rostaing, Stephane; Popowycz, Florence; Lemaire, Marc Tetrahedron Letters, 2010 , vol. 51, # 48 p. 6290 - 6293

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Citation Number: 10

Abstract

Indolizidine alkaloids 1 , bearing an azabicyclic ring skeleton, have been mainly isolated in small quantities from the skin extracts of neotropical frogs (Dendrobatidae, Mantellinae, Myobatrachidae, and Bufonidae) 2 and have displayed a wide range of biological properties, especially as non-competitive nicotinic inhibitors. These molecules are potent blockers of nicotinic acetylcholine receptor channels (nAChRs), suggesting their potential ...