Diether derivatives of homo-or substituted piperidines as non-imidazole histamine H 3 receptor ligands

…, W Schunack, H Stark, K Kieć-Kononowicz

Index: Lazewska, Dorota; Kuder, Kamil; Ligneau, Xavier; Camelin, Jean-Claude; Schunack, Walter; Stark, Holger; Kiec-Kononowicz, Katarzyna Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 8 p. 3037 - 3042

Full Text: HTML

Citation Number: 8

Abstract

Synthesis and biological activities of a series of homo-or substituted piperidine unsymmetrical diethers are described. The novel compounds were evaluated for histamine H3 receptor binding affinities at recombinant human H3 receptor stably expressed in HEK- 293 cells. All diethers showed in vitro affinities in nanomolar concentration range. The most potent compounds are 1-[3-(3-(4-chlorophenoxy) propoxy) propyl]-3-methylpiperidine 11 ( ...