Cynogen bromide and ethylacetoacetate in heterocyclization: Novel synthesis of tetracyclic derivative of 3??aryl quinazolinones

MB Deshmukh, SS Patil, SS Patil…

Index: Deshmukh; Patil, Suresh S.; Patil, Sanjeevani S.; Jadhav, Swati D. Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 5 p. 1144 - 1147

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Citation Number: 3

Abstract

Quinazoline derivatives have attracted considerable attention due to their significant biological activities [1, 2], especially antifungal [3, 4], insecticidal [5], antihistaminic [6], anti- inflammatory [7], antibacterial [8], anticonvulsant [9, 10], antithrombotic [11], antitubercular [12], and antitumor [13]. In this article, we report a new route for the synthesis of triazolo and tetracyclic derivatives of quinazolinone.