Synthesis and quantification of DNA adducts of 4, 4'-methylenedianiline

…, P Sagelsdorff, O Sepai, G Sabbioni

Index: Schuetze, Dietrich; Sagelsdorff, Peter; Sepai, Ovnair; Sabbioni, Gabriele Chemical Research in Toxicology, 1996 , vol. 9, # 7 p. 1103 - 1112

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Citation Number: 32

Abstract

4, 4'-Methylenedianiline (MDA) is used as a hardener in the manufacture of plastics and polyurethanes. MDA has been classified as a carcinogen in animals and is a suspected human carcinogen. Assuming that MDA would yield similar DNA adducts to other arylamines, we synthesized the following C-8 guanine adducts: N'-acetyl-N-(deoxyguanosin- 8-yl)-MDA, N-(deoxyguanosin-8-yl)-MDA, N-(deoxyguanosin-8-yl)-4MA, and their ...