Evaluation of N-(2-Thienylidene) amines, N-(2-Hydroxybenzylidene) amines and 3-Iminoindolin-2-ones as Antileishmanial Agents

Y MSA Al-Kahraman, GS Singh…

Index: Al-Kahraman, Yasser M.S.A.; Singh, Girija S.; Yasinzai, Masoom Letters in Drug Design and Discovery, 2011 , vol. 8, # 5 p. 491 - 495

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Citation Number: 6

Abstract

The paper describes the synthesis and antileishmanial activity of N-substituted imines, obtained from the reactions of primary amines with three biologically important aldehydes/ketones, thiophene-2-carbaldehyde, 2-hydroxybenzaldehyde (salicylaldehyde) and indoline-2, 3-dione. Of the fourteen compounds screened from three classes, five compounds showed significant antileishmanial activity. Among the three classes of imines ...