Synlett
A Very Mild Access to 3, 4-Dihydroisoquinolines Using Triphenyl Phosphite-Bromine-Mediated Bischler-Napieralski-Type Cyclization
D Vaccari, P Davoli, C Ori, A Spaggiari, F Prati
Index: Vaccari, Daniele; Davoli, Paolo; Ori, Claudia; Spaggiari, Alberto; Prati, Fabio Synlett, 2008 , # 18 p. 2807 - 2810
Full Text: HTML
Citation Number: 2
Abstract
Abstract Substituted β-phenylethylamides undergo smooth intramolecular cyclization to 3, 4- dihydroisoquinolines in good to excellent yields when treated with bromotriphenoxyphosphonium bromide at-60 C in dichloromethane in the presence of triethylamine. The reaction proceeds under the mildest conditions ever reported for Bischler- Napieralski-type cyclizations. When chlorotriphenoxyphosphonium choride is used, low ...