Journal of the American Chemical Society

Condensation reactions. I. The condensation of ketones with cyanoacetic esters and the mechanism of the Knoevenagel reaction

AC Cope

Index: Cope Journal of the American Chemical Society, 1937 , vol. 59, p. 2327,2329

Full Text: HTML

Citation Number: 81

Abstract

This paper describes a series of alkylidene cyanoacetic esters, ReC= C (CN) COOR, prepared by condensing ten simple ketones with methyl cyanoacetate. Several unsaturated cyano esters of this type have been prepared previously by the Knoevenagel reaction, with secondary amines such as piperidine'and diethylamine2 as catalysts. Sodium ethoxide3 and the zinc chlorideaniline complex4 have also been employed as condensing agents.