Hydrolyzed Metabolites of Thalidomide: Synthesis and TNF-. ALPHA. Production-Inhibitory Activity

T Nakamura, T Noguchi, H Miyachi…

Index: Nakamura, Takanori; Noguchi, Tomomi; Miyachi, Hiroyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 4 p. 651 - 654

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Citation Number: 13

Abstract

Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido) glutarimide was a more potent TNF-α production inhibitor than thalidomide.