Chemistry Letters

An Efficient Synthesis of α-Keto Amides via Reaction of α-(N-Methylanilino)-acetonitrile with Esters Followed by Hydrolysis using Copper (II) Acetate

K Takahashi, K Shibasaki, K Ogura, H Iida

Index: Takahashi, Kazumasa; Shibasaki, Kenichiro; Ogura, Katsuyuki; Iida, Hirotada Chemistry Letters, 1983 , p. 859 - 862

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Citation Number: 13

Abstract

An efficient sequence proposed for the conversion of esters to α-keto amides involves the reaction of α-(N-methylanilino)-acetonitrile with esters to afford β-hydroxy-α-cyanoenamines of which hydrolysis using copper (II) acetate gives the corresponding α-keto amides in good yields.