Synthesis and quantitative structure-activity relationships of antiallergic 2-hydroxy-N-(1H-tetrazol-5-yl) benzamides and N-(2-hydroxyphenyl)-1H-tetrazole-5- …
RE Ford, P Knowles, E Lunt, SM Marshall…
Index: Ford; Knowles; Lunt; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 538 - 549
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Citation Number: 99
Abstract
The synthesis and antiallergic activity of a series of 2-hydroxy-N-1H-tetrazol-5-ylbenzamides and isomeric N42-hydroxyphenyl)-lH-tetrazole-5-carboxamides is described. A relationship between structure and intravenous antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test has been established using a Hansch/Free-Wilson model and used to direct studies toward potent derivatives. The contribution of physicochemical properties ...
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