Synthesis and antitumor activity of 1-acetyl-3-(4-phenyl)-4, 5-dihydro-2-pyrazoline-5-phenylursolate and 4-chalcone ursolate derivatives

X Bai, WQ Shi, HF Chen, P Zhang, Y Li…

Index: Bai, Xue; Shi, Wan Qi; Chen, Hua Feng; Zhang, Ping; Li, Ying; Yin, Shu Fan Chemistry of Natural Compounds, 2012 , vol. 48, # 1 p. 60 - 65

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Citation Number: 4

Abstract

New 4-chalcone ursolate and 1-acetyl-3-(4-phenyl)-4, 5-dihydro-2-pyrazoline-5-phenyl ursolate derivatives were synthesized by esterification of UA and chalcone or pyrazoline. The compounds were structurally confirmed by IR, 1 H NMR, 13 C NMR, and HR-MS spectroscopy. The cytotoxicity of ten derivatives was evaluated against A549, SKOV3, and HepG2 cell lines by MTT assay. The result showed that several compounds were more ...