Chemical communications

Hemiaminals as substrates for sulfur ylides: Direct asymmetric syntheses of functionalised pyrrolidines and piperidines

CG Kokotos, VK Aggarwal

Index: Kokotos, Christoforos G.; Aggarwal, Varinder K. Chemical Communications, 2006 , # 20 p. 2156 - 2158

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Citation Number: 21

Abstract

Phenyl stabilised chiral sulfur ylides react with five-membered-ring hemiaminals to give functionalised pyrrolidines directly with high enantioselectivity. The reaction can be diverted to give piperidines instead by isolation of the intermediate epoxide and treatment with TMSOTf.

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