Chemoenzymatic Synthesis of 3′-Deoxy-3′-(4-Substituted-Triazol-1-YL)-5-Methyluridine

…, R Kumar, V Kumar, CE Olsen, RK Saxena…

Index: Arya, Anu; Mathur, Divya; Tyagi, Abhilash; Kumar, Rajesh; Kumar, Vinod; Olsen, Carl E.; Saxena, Rajendra K.; Prasad, Ashok K. Nucleosides, Nucleotides and Nucleic Acids, 2013 , vol. 32, # 12 p. 646 - 659

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Abstract

An efficient protocol has been developed for the synthesis of a small library of 3′-deoxy-3′- (4-substituted-triazol-1-yl)-5-methyluridine using Cu (I)-catalyzed Huisgen–Sharpless– Meldal 1, 3-dipolar cycloaddition reaction of 3′-azido-3′-deoxy-5-methyluridine with different alkynes under optimized condition in an overall yields of 76%–92%. Here, the azido precursor compound, ie, 3′-azido-3′-deoxy-5-methyluridine was chemoenzymatically ...

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