A Six-Step Synthesis of (.+-.)-Camptothecin

DL Comins, H Hong, JK Saha…

Index: Comins, Daniel L.; Hong, Hao; Saha, Jayanta K.; Jianhua, Gao Journal of Organic Chemistry, 1994 , vol. 59, # 18 p. 5120 - 5121

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Citation Number: 113

Abstract

Summary: A six-step synthesis of (f bcamptothecin has been achieved starting from 2-methoxypyridine and 2-bromoquinoline. The antitumor alkaloid camptothecin (1) has attracted much attention over the years since its isolation in 1966.' Camptothecin has a long, rich history1v2 as a potential anticancer agent, and it has recently reemerged as one of the most important lead compounds among the anti- tumor natural products. Several syntheses of camptoth-

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