Determination of quinacrine dihydrochloride dihydrate stability and characterization of its degradants

…, P Espeau, Y Corvis, F Guyon, B Do

Index: Rotival, Romain; Espeau, Philippe; Corvis, Yohann; Guyon, Francois; Do, Bernard Journal of Pharmaceutical Sciences, 2011 , vol. 100, # 8 p. 3223 - 3232

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Citation Number: 3

Abstract

Abstract Although quinacrine dihydrochloride dihydrate is a widely used drug substance, a comprehensive determination of its stability profile is lacking. In this work, an integrative approach is implemented to determine the drug stability both in the solid state and aqueous solutions, identify the impurities that can be found in the active pharmaceutical ingredient, and evaluate the associated toxicity risks. Thermal analyses pointed out a two-step ...