6α??and 6β??methyl steroids in the 19??nor series

CC Bolt, AJ van Den Broek, GH Visser…

Index: Bolt,C.C. et al. Recueil des Travaux Chimiques des Pays-Bas, 1971 , vol. 90, p. 849 - 860

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Abstract

Abstract The dehydration-epimerization reaction applied to a 5α-hydroxy-6β-methyl-3-oxo- 19-nor-steroid, under acid conditions, leads to a mixture of the 6α-methyl-3-oxo-Δ 4-19-nor- steroid and its 6β-epimer. This is in contrast to the normal steroid series, in which exclusively the 6α-methyl epimer is formed. A complete conversion to the 6α-methyl compounds can be achieved by alkaline hydrolysis of the corresponding 3-acetoxy-6-methyl-Δ 3, 5 ...