Tetrahedron letters

Aldol condensation of amides using phosphazene-based catalysis

SW Foo, S Oishi, S Saito

Index: Foo, Siong Wan; Oishi, Shun; Saito, Susumu Tetrahedron Letters, 2012 , vol. 53, # 40 p. 5445 - 5448

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Citation Number: 5

Abstract

We have developed a new method for the direct aldol condensation of unactivated amides using 1, 3, 5-triazo-2, 4, 6-triphosphorine-2, 2, 4, 4, 6, 6-hexachloride (TAPC)-based phosphorous/SO42− catalysis. The SO42− species in a reaction mixture enhances the reaction rate of the catalysis. In principle, no metal sources are required for the generation of the catalyst, and there is no requirement for the use of stoichiometric quantities of an acid ...

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