Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors.
…, H Zhao, S Sunder, TR Burke, RJ Schultz…
Index: Neamati, Nouri; Mazumder, Abhijit; Zhao, He; Sunder, Sanjay; Burke Jr., Terrence R.; Schultz, Robert J.; Pommier, Yves Antimicrobial Agents and Chemotherapy, 1997 , vol. 41, # 2 p. 385 - 393
Full Text: HTML
Citation Number: 101
Abstract
ABSTRACT A majority of reported human immunodeficiency virus type 1 integrase (HIV-1 IN) inhibitors are polyhydroxylated aromatic compounds containing two phenyl rings separated by aliphatic or aromatic linkers. Most inhibitors possessing a catechol moiety exhibit considerable toxicity in cellular assays. In an effort to identify nonhydroxylated analogs, a series of aromatic sulfones were tested for their ability to inhibit the 3' ...
Related Articles:
[Ullmann; Korselt Chemische Berichte, 1907 , vol. 40, p. 645]
[Glutz Justus Liebigs Annalen der Chemie, 1868 , vol. 147, p. 52]
[Ullmann; Korselt Chemische Berichte, 1907 , vol. 40, p. 645]
[Ullmann; Korselt Chemische Berichte, 1907 , vol. 40, p. 645]