The Journal of organic chemistry

Conversion of bromoalkenes into alkynes by wet tetra-n-butylammonium fluoride

M Okutani, Y Mori

Index: Okutani, Masaru; Mori, Yuji Journal of Organic Chemistry, 2009 , vol. 74, # 1 p. 442 - 444

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Citation Number: 65

Abstract

Tetra-n-butylammonium fluoride was found to be a mild and efficient base for the elimination reaction of bromoalkenes. Treatment of 1, 1-dibromoalkenes,(Z)-1-bromoalkenes, and internal bromoalkenes with 5 equiv of TBAF· 3H2O in DMF yielded terminal and internal alkynes in high yields without undue regard to the presence of water.