Journal of medicinal chemistry

Derivatives of Fluorene. XXIV. 1 Synthesis and Antitumor Activities of Some Imidazolidine-2, 5-diones

HL Pan, TL Fletcher

Index: Pan,H.-L.; Fletcher,T.L. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 957 - 959

Full Text: HTML

Citation Number: 14

Abstract

Because of the biological activity of certain imidazolidinedio~ ies,~~~ we are synthesizing a number of such compounds incorporating variously substituted fluorene nuclei, connected through their 9 posit, ions (spirohydantoins), and through their 2 positions (4-fluorenyl-4- methylimidazolidinediones). This is part, of a pro-gram aimed at exploiting the fact that a number of fluorene compounds (particularly halogen-substituted derivatives) have shown ...